Cardiovascular and respiratory diseases are significant public health issues affecting millions of individuals globally and burdening healthcare systems tremendously. StethX has developed a smart, easy-to-use and low-profile wearable patch for accurate detection, analysis and quantification of heart sounds and respiratory abnormalities by capturing mechano-acoustic signals emanated from heart and lung. In this talk, an overview of the capabilities of the patch for longitudinal monitoring and at-home use will be discussed and the latest clinical results from the patch will be presented.